Managing secondary mitral regurgitation continues to be challenging and the cover story of the April issue highlights current approaches and perspective from leading experts, including the key role of the Heart Team. TAVR is a disruptive innovation that has truly transformed care for hundreds of thousands of people with severe aortic stenosis worldwide without other treatment options. The 20th anniversary of TAVR is marked with a conversation with Alain Cribier, MD, FACC, who performed the first TAVR procedure and a perspective from the front row seats by David R. Holmes Jr., MD, MACC, and Michael J. Mack, MD, MACC, on how TAVR solidified Heart Teams, built a registry and the power of collaboration between peer societies and regulatory agencies. The Editor’s Corner by Peter Block, MD, FACC, shares more about the history and challenges of moving this new technology from concept to patients. Also in this issue, Rheana Harrilal, MD, MPH; Darshana Nair, MD; and Julia Grapsa, MD, PhD, FACC, provide an update on infective endocarditis and highlight JACC Patient Care Pathways, and Ed Chu, MD, discusses the potential of cardioneuroablation. Don’t miss two articles with new research data presented at ACC.22, one showing the racial minorities are less likely to receive bystander CPR and another showing that women continue to be missing from the leadership of clinical trials. And, get to know Ed Fry, MD, FACC, the new president of ACC. Get the full issue at ACC.org/Cardiology and don’t forget to follow @ACCinTouch and use #CardiologyMag to share your favorite articles and join in discussions.