The latest issue of Cardiology magazine highlights the advances in the past year that are helping us to transform cardiovascular practice and improve heart health, and takes a deep dive into the treatment of patients with heart failure with preserved ejection fraction, shedding light on research findings that are bringing new hope, including the potential of SGLT2 inhibitors. Also in this issue, learn about important advances in heart failure, cardiomyopathies, mechanical circulatory support and cardiac transplantation, read about the Top 10 key trials in 2021, and catch the major highlights from the new 2021 Coronary Revascularization Guideline. Additionally, read more about the challenges facing clinicians and patients when it comes to treating familial hypercholesterolemia based on a recent survey of ACC members. Follow Cardiology on Twitter using #CardiologyMag and get the full issue here.